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Tylex CD Codeine/Paracetamol 30/500 mg 30 Caps

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Tylex CD is a medication with analgesic and antipyretic properties, it contains paracetamol and codeine.

 

What does Tylex CD contain and how does it work

It is a combined preparation containing 500 mg of paracetamol and 30 mg of codeine. Paracetamol has an analgesic and antipyretic effect. It works by inhibiting the activity of cyclooxygenase 2 in the brain and in the spinal cord, an enzyme responsible for the synthesis of prostaglandins. Paracetamol has no anti-inflammatory effect as it practically does not inhibit the activity of cyclooxygenases and prostaglandin synthesis in peripheral tissues. Tylex CD does not damage the gastric mucosa. It does not inhibit platelet aggregation and does not affect the coagulation process. The second component of the Tylex is codeine (30mg), an opioid analgesic that acts on the central nervous system. Codeine is metabolized to the active metabolite - morphine, with the participation of the 2D6 cytochrome P450 isoenzyme. The analgesic effect of codeine may not be sufficient in some people. On the contrary, in the case of increased activity of this isoenzyme, there is a risk of opioid toxicity, even at the usual recommended doses.

The preparation exhibits a longer and stronger analgesic effect than each of the active substances used alone. After oral administration, paracetamol and codeine are well absorbed from the gastrointestinal tract. The maximum concentration of Tylex CD paracetamol in the blood is obtained after 30-60 minutes, and codeine - 60 minutes after taking the preparation. Both components of the preparation penetrate the placenta and also into breast milk.

 

Uses of Tylex CD

Tylex is indicated for moderate to severe persistent pain after the use of pain relievers with peripheral action (the drug is not effective in the treatment of phantom pain, neurogenic).

Tylex CD codeine is indicated in teenagers after 12 years of age, for the treatment of moderate acute pain that does not disappear with paracetamol alone or with other pain relievers used as monotherapy, such as ibuprofen.

 

Where not to take medication

Unfortunately, even if there are indications for the use of the Tylex CD, it can not always be used. You must not use this medicine if you are allergic (hypersensitive) to any of the ingredients.

The use of the drug is contraindicated in people:

  • severe renal or hepatic impairment
  • with alcohol sickness
  • glucose-6-phosphate dehydrogenase deficiency
  • taking concomitant or past 2 weeks of MAO inhibitors before taking Tylex CD
  • opioid agonists and antagonists (e.g. buprenorphine, nalbuphine, pentazocine)
  • with respiratory failure, regardless of its severity
  • with bronchial asthma
  • in children up to 12 years of age (risk of toxic effects of opioid drugs)
  • in children and adolescents up to 18 years of age after Palatine and/or pharyngeal tonsil removal as a treatment for Obstructive Sleep Apnea Syndrome
  • rapidly metabolizing drugs with the participation of cytochrome P450 isoenzyme 2D6
  • in women in the first trimester of pregnancy and breastfeeding
  • in children weighing less than 33 kg (up to 12 years old).

 

Dosage of Tylex CD

It is available as effervescent tablets for oral use. Do not exceed the recommended doses as this will not increase the effectiveness of the Tylex CD and may harm your health and life. If you have any further questions on the use of this product, ask your doctor for advice.

It is intended for use in adults and adolescents weighing more than 33 kg (after 12 years of age). It should be taken after dissolving the tablet in a glass of water. Do not chew or swallow the undiluted tablet.

Adults: 1 tablet 1-3 times a day. Do not use Tylex CD more frequently than every 6 hours. In case of severe pain, you can take 2 tablets at a time. Usually, you should not take more than 6 tablets a day. In case of very severe pain, the dose can be increased to 8 tablets per day, which is the maximum daily dose.

Do not use more than 4 g of paracetamol and 240 mg of codeine per day.

In the elderly, the starting dose should be halved. Your doctor may then advise you to increase the dose if you are well tolerated and need to take higher doses.

In case of impaired renal function, it may be necessary to increase the Tylex CD dose interval (consult your doctor). If creatinine clearance is less than 50 ml / min but greater than 10 mL / min do not use more frequently than every 6 hours. If creatinine clearance is less than 10 mL / min do not use more frequently than every 8 hours.

In case of liver dysfunction, active well-controlled liver disease, chronic alcoholic disease, malnutrition or dehydration, a dose of more than 3 g of paracetamol per day should not be used. It is also advisable to reduce the dose of Tylex CD codeine (consult your doctor).

Children and adolescents after 12 year of life:

When used in children, the dose should be adjusted according to the child's weight. The recommended dose of paracetamol is 10-15 mg / kg body weight every 4-6 hours. The maximum dose of Tylex CD paracetamol is 60 mg / kg body weight per day, in divided doses (up to 3 g of paracetamol per day for a patient weighing 50 kg).

Children weighing 33-50 kg: once 1 tablet, if necessary, the dose can be repeated every 6 hours, do not use more than 4 tablets per day (2 g of paracetamol and 120 mg of codeine).

Adolescents weighing more than 50 kg: once 1 tablet, if necessary, the dose can be repeated up to 3 times a day, not more often than every 6 hours. In case of severe pain, you can take 2 tablets of Tylex CD at a time. Usually, you should not take more than 6 tablets a day. In case of very severe pain, the dose can be increased to 8 tablets per day, which is the maximum daily dose. Do not use more than 4 g of paracetamol and 240 mg of codeine per day.

In children with renal insufficiency, close medical supervision is necessary (risk of accumulation of paracetamol and codeine in the body). If necessary, your doctor will advise you to reduce your dose of Tylex CD. In this group of patients, the interval between doses should be at least 8 hours. Carefully monitor the condition of the child.

Tylex CD Codeine should be used at the lowest effective dose for the shortest possible time.

Regular use will avoid fluctuations in the severity of pain and fever. The interval between doses should not be less than 6 hours.

Do not use for more than 3 days without consulting your doctor. If significant pain relief is not obtained, consult a doctor. Do not use Tylex in children under 12 years old.

 

This product is a controlled substance in Mexico and requires a doctor’s approval and prescription. The cost for the prescription and approval from the independant doctor is included in the purchase price of this medicine. This and other medicines similar will be screened for possible combinations by your approving doctor that may be harmful if taken together. here is no cost and a refund will be issued for the total price if your doctor does not approve your prescription. TYLEX CD Active Ingredients Tylex 30 capsules contain 30MG Codeine Phosphate and 500MG Paracetamol. What is codeine? Codeine is in a group of drugs called narcotic pain medicines. Codeine is used to treat mild to moderate pain. Codeine may also be used for purposes other than those listed in this medication guide. What is the most important information I should know about codeine? Codeine may be habit-forming and should be used only by the person it was prescribed for. Codeine should never be given to another person, especially someone who has a history of drug abuse or addiction. Keep the medication in a secure place where others cannot get to it. Do not drink alcohol while you are taking codeine. Dangerous side effects or death can occur when alcohol is combined with a narcotic pain medicine. Check your food and medicine labels to be sure these products do not contain alcohol. Never take more than your prescribed dose of codeine. Tell your doctor if the medicine seems to stop working as well in relieving your pain. Codeine can cause side effects that may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be awake and alert. Do not stop using codeine suddenly, or you could have unpleasant withdrawal symptoms. Talk to your doctor about how to avoid withdrawal symptoms when stopping the medication. What should I discuss with my healthcare provider before taking codeine? Do not use codeine if you have ever had an allergic reaction to a narcotic medicine (examples include codeine, methadone, morphine, Oxycontin, Darvocet, Percocet, Vicodin, Lortab, and many others). You should also not take codeine if you are having an asthma attack or if you have a bowel obstruction called paralytic ileus. Codeine may be habit-forming and should be used only by the person it was prescribed for. Codeine should never be given to another person, especially someone who has a history of drug abuse or addiction. Keep the medication in a secure place where others cannot get to it.

Before using codeine, tell your doctor if you are allergic to any drugs, or if you have:

  • asthma, COPD, sleep apnea, or other breathing disorders;
  • liver or kidney disease;
  • underactive thyroid;
  • curvature of the spine;
  • a history of head injury or brain tumor;
  • epilepsy or other seizure disorder;
  • low blood pressure;
  • gallbladder disease;
  • Addison's disease or other adrenal gland disorders;
  • enlarged prostate, urination problems;
  • mental illness; or
  • a history of drug or alcohol addiction.

FDA pregnancy category C. Codeine may be harmful to an unborn baby, and could cause breathing problems or addiction/withdrawal symptoms in a newborn. Tell your doctor if you are pregnant or plan to become pregnant during treatment. Codeine can pass into breast milk and may harm a nursing baby. The use of codeine by some nursing mothers may lead to life-threatening side effects in the baby. Do not use this medication without telling your doctor if you are breast-feeding a baby. Older adults may be more sensitive to the effects of this medicine.

ReviewsTylex CD Codeine/Paracetamol 30/500 mg 30 Caps
Sharon
08/11/2021
100
Thank goodness for the pain relief!

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