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Provigil Modiodal Modafinil 200 mg 14 Tabs.

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The drug Modiodal is used to control drowsiness in the background of narcolepsy. It can be used for ADHD symptoms in adult patients. It’s an FDA-approved medication that stimulates the nervous system. The drug may cause side effects and addiction, so its administration is always controlled by the attending physician.

Form and active ingredient

The active component of the drug is Modafinil. It’s an effective nootropic and analeptic. In the United States, the drug is available in the form of tablets for oral administration. There are 14 tablets in one pack. Each tablet contains 20 mg of the active ingredient.

Modafinil is absorbed into the systemic bloodstream through the gastrointestinal tract. Its bioavailability reaches 80%. The maximum concentration is registered 2-3 hours after intake. The rate of absorption is reduced when taking the tablets with food. 

The drug is eliminated in 10-12 hours. The main metabolism takes place in the liver cells. Inactive forms of modafinil are excreted with urine. 

Pharmacological action

The exact mechanism of action of the drug is not known. It’s assumed that Modafinil provokes an increase in the concentration of a number of hormones, namely dopamine, noradrenaline, and serotonin. The drug directly affects the hypothalamus. Neuropeptides responsible for sleep and wakefulness cycles are included in the process. Further, histamine molecules are released in the brain. As a result, the period of arousal is prolonged. 

During taking the drug, drowsiness disappears performance increases, cognitive functions - attention, thinking, memory - are stimulated, the risk of depressive states decreases, and mood improves.

When Modafinil is prescribed

The drug is used to treat narcolepsy and ADHD. As an experimental drug, the use of the tablets is possible in multiple sclerosis, bipolar affective disorder, cognitive recovery after chemotherapy, cirrhosis of the liver, and significant weight loss. 

Limitations in treating drowsiness

Modafinil cannot be taken if there are contraindications. Admission is not possible in the case of:

  • individual intolerance;

  • cardiovascular disease, including a history of the disease;

  • pregnancy and lactation;

  • severe kidney disease.

Possible side effects

Modafinil may provoke myalgia; headaches; nasal congestion; nausea; diarrhea; dizziness; anxiety; insomnia; skin rashes; shortness of breath.

Severe side effects include swelling, trouble swallowing and breathing, fever, darkening and decreased urine. The above symptoms require hospitalization and further monitoring of well-being.

Overdose of the drug

When violating the instructions and taking excessively large doses, intoxication with the active substance is not excluded. Modafinil provokes hypertension and tachycardia. In severe cases, the risk of hypertensive crisis, respiratory depression, loss of consciousness, coma, and death increases. 

Additional Notes

Modafinil shouldn’t be combined with other CNS stimulants to avoid side effects and drug intoxication. It’s not recommended to combine the drug with oral contraceptives. Alcohol is prohibited during treatment.

Analeptic can cause addiction and withdrawal syndrome. Tolerance to the active substance is developed when taking higher doses. This can cause cognitive disorders, depression, and general deterioration of well-being.

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