The drug Cyclobenzaprine is an effective remedy for relaxing muscles and relieving spasms. It is used as an analgesic as part of complex therapy. The action of the drug can be supplemented with rest and physical therapy methods. Cyclobenzaprine is prescribed when recovering from injuries and operations, acute muscle pain of any etiology. Available with a prescription from the doctor.
Cyclobenzaprine is an effective agent for relaxing muscles and relieving spasms. It is used as an analgesic as part of a comprehensive therapy. The action of the drug can be supplemented by rest and physiotherapy methods. Cyclobenzaprine is prescribed in recovery from injuries and surgeries, in acute muscle pain of any etiology. Released by doctor's prescription.
Form of production and active ingredient
In the United States and Mexico, Cyclobenzaprine is available in the form of capsules for oral administration. One package contains 30 tablets. The proportion of the active ingredient is 10/250 mg. The drug relieves muscle tension and eliminates pain due to the inclusion of cyclobenzaprine.
This compound was approved for widespread medical use in the United States in 1977. Chemically, it is a tricyclic amine of synthetic origin. Its properties are similar to amitriptyline. Originally, cyclobenzaprine was seen as a treatment for headaches and for depression. Later, scientists recorded a powerful myorelaxant effect of the substance.
The myotropic antispasmodic is 93% bound to plasma proteins. The maximum bioavailability of the active substance is 55%, the minimum - 33%. Metabolites are excreted mainly by the kidneys. The highest concentration of cyclobenzaprine in the blood is fixed 8 hours after intake. The substance is completely eliminated from the body 37 hours after intake.
Mechanism of action of the drug
Cyclobenzaprine Yuredol capsules eliminate spasms without direct effect on the muscle frame. There is no suppression of muscle fiber function. Synapses are also not affected.
Complete elimination or significant reduction of smooth muscle hypertonicity is achieved through the effect of cyclobenzaprine on brainstem tissues. The active substance blocks the signals from the periphery to the CNS. Additionally, the drug affects the functioning of the spinal cord.
The result is a relaxing effect. Against the background of treatment, tonic motor activity decreases, and a moderate sedative effect is provided. The patient is relieved of discomfort and muscle pain.
Indications for use of Cyclobenzaprine
Smooth muscle spasms cannot be ignored. They not only significantly worsen the quality of life, but also contribute to the further development of the disease. For pain relief, effective muscle relaxants are prescribed.
Cyclobenzaprine capsules are used for the following indications:
- Acute or chronic pathologies of the musculoskeletal system;
- Fibromyalgia of unknown genesis;
- Rehabilitation after injuries - sprains or tears, fractures, contusions;
- Rehabilitation after surgery on the joints.
Cyclobenzaprine capsules can be used as part of complex therapy in the treatment of tetanus. The drug complements the antibacterial agents. It gets rid of cramps and relieves painful muscle tension.
The exact dosage of the drug is selected by the attending physician individually for each patient. The course of treatment lasts for two to four weeks. Further use of the drug willn’t bring a positive effect, because it doesn’t exclude the habituation of the active component.
The capsules should be swallowed whole, without chewing, followed by 200 ml of water. The drug is taken every day at the same time. It’s better to time the reception in the morning. This will allow you to control the state of the body.
Restrictions on the reception of capsules
The list of contraindications to the prescription of Cyclobenzaprine includes the following items:
- hypersensitivity to the components of the capsules;
- under 18 years of age;
- hyperfunction of the thyroid gland and pituitary gland;
- myocardial infarction.
Cyclobenzaprine cannot be taken simultaneously with monoamine oxidase inhibitors. After completion of the course at least 14 days should pass.
Possible to take during pregnancy and lactation
Adequate studies confirming the teratogenic effect of the active component on the fetus haven’t been conducted. Administration of Cyclobenzaprine to pregnant women is possible strictly on indication if no alternative treatment is available.
If a muscle relaxant is used after delivery, lactation should be stopped. There’re no data on the penetration of Cyclobenzaprine into breast milk. However, based on the similarity of the active component with tricyclic antidepressants, it can be assumed that the negative effect on the body of a child who is breastfed.
Combination with alcohol
Cyclobenzaprine shouldn’t be taken simultaneously with alcoholic beverages. The combination of ethanol and Cyclobenzaprine is life-threatening. If this rule is violated, symptoms of acute intoxication develop: vomiting, tachycardia, confusion. Hallucinations, depression of the respiratory center are possible.
During treatment with Cyclobenzaprine Yuredol capsules, unwanted effects from different organ systems may occur. The most frequently diagnosed are:
- dry mouth;
- tremors of the extremities;
- slurred speech;
- increased fatigue;
The risk and severity of side effects increase with age. A number of experts don’t recommend the use of Cyclobenzaprine to relieve muscle cramps in the elderly.
Overdose of the drug
Using the drug in therapeutic doses under medical supervision is safe. An independent increase in the dose is fraught with poisoning. Signs of cyclobenzaprine intoxication: hallucinations, delirium, confusion, tachycardia.
When poisoning with the drug to critical levels, blood pressure decreases. Life-threatening states - complete blockage of nerve impulse transmission, depression of the respiratory center, coma.
- Gastric lavage - relevant if the patient is conscious;
- Taking sorbents - activated charcoal in a dose calculated by body weight;
- intravenous injections of sodium bicarbonate;
- hyperventilation of the lungs in case of severe arrhythmia;
- administration of benzodiazepines for uncontrollable seizures.
Regular monitoring of blood pressure values is necessary during the recovery period. The patient is given an ECG to assess the work of the heart. If medical help is sought in time, the prognosis is favorable.
To avoid increasing side effects, it’s not recommended to take Cyclobenzaprine simultaneously with other drugs that have antispasmodic action. It is forbidden to combine capsules with antidepressants, neuroleptics.
Cyclobenzaprine may reduce the effectiveness of agents used for sedation during surgical interventions. It is recommended to temporarily stop taking Cyclobenzaprine capsules before the planned surgery.
Decreased concentration, drowsiness, confusion may occur during treatment. It is recommended to refrain from driving vehicles.